Stretchable electrochemical impedance sensors for intravascular detection of lipid-rich lesions in New Zealand White rabbits.
Identifieur interne : 001166 ( Main/Exploration ); précédent : 001165; suivant : 001167Stretchable electrochemical impedance sensors for intravascular detection of lipid-rich lesions in New Zealand White rabbits.
Auteurs : Hung Cao [États-Unis] ; Fei Yu [États-Unis] ; Yu Zhao [États-Unis] ; Nick Scianmarello [États-Unis] ; Juhyun Lee [États-Unis] ; Wangde Dai [États-Unis] ; Nelson Jen [États-Unis] ; Tyler Beebe [États-Unis] ; Rongsong Li [États-Unis] ; Ramin Ebrahimi [États-Unis] ; Donald S. Chang [États-Unis] ; Freny V. Mody [États-Unis] ; John Pacella [États-Unis] ; Yu-Chong Tai [États-Unis] ; Tzung Hsiai [États-Unis]Source :
- Biosensors & bioelectronics [ 1873-4235 ] ; 2014.
Descripteurs français
- KwdFr :
- Animaux, Aorte (anatomopathologie), Athérosclérose (anatomopathologie), Athérosclérose (diagnostic), Conception d'appareillage, Impédance électrique, Lapins, Lipides (analyse), Lipoprotéines LDL (analyse), Mâle, Plaque d'athérosclérose (diagnostic), Spectroscopie diélectrique (instrumentation), Techniques de biocapteur (instrumentation).
- MESH :
- analyse : Lipides, Lipoprotéines LDL.
- anatomopathologie : Aorte, Athérosclérose.
- diagnostic : Athérosclérose, Plaque d'athérosclérose.
- instrumentation : Animaux, Conception d'appareillage, Impédance électrique, Lapins, Mâle, Spectroscopie diélectrique, Techniques de biocapteur.
English descriptors
- KwdEn :
- Animals, Aorta (pathology), Atherosclerosis (diagnosis), Atherosclerosis (pathology), Biosensing Techniques (instrumentation), Dielectric Spectroscopy (instrumentation), Electric Impedance, Equipment Design, Lipids (analysis), Lipoproteins, LDL (analysis), Male, Plaque, Atherosclerotic (diagnosis), Rabbits.
- MESH :
- chemical , analysis : Lipids, Lipoproteins, LDL.
- diagnosis : Atherosclerosis, Plaque, Atherosclerotic.
- instrumentation : Biosensing Techniques, Dielectric Spectroscopy.
- pathology : Aorta, Atherosclerosis.
- Animals, Electric Impedance, Equipment Design, Male, Rabbits.
Abstract
Flexible electronics have enabled catheter-based intravascular sensing. However, real-time interrogation of unstable plaque remains an unmet clinical challenge. Here, we demonstrate the feasibility of stretchable electrochemical impedance spectroscopy (EIS) sensors for endoluminal investigations in New Zealand White (NZW) rabbits on diet-induced hyperlipidemia. A parylene C (PAC)-based EIS sensor mounted on the surface of an inflatable silicone balloon affixed to the tip of an interrogating catheter was deployed (1) on the explants of NZW rabbit aorta for detection of lipid-rich atherosclerotic lesions, and (2) on live animals for demonstration of balloon inflation and EIS measurements. An input peak-to-peak AC voltage of 10 mV and sweeping-frequency from 300 kHz to 100 Hz were delivered to the endoluminal sites. Balloon inflation allowed EIS sensors to be in contact with endoluminal surface. In the oxidized low-density-lipoprotein (oxLDL)-rich lesions from explants of fat-fed rabbits, impedance magnitude increased significantly by 1.5-fold across the entire frequency band, and phase shifted ~5° at frequencies below 10 kHz. In the lesion-free sites of the normal diet-fed rabbits, impedance magnitude increased by 1.2-fold and phase shifted ~5° at frequencies above 30 kHz. Thus, we demonstrate the feasibility of stretchable intravascular EIS sensors for identification of lipid rich lesions, with a translational implication for detecting unstable lesions.
DOI: 10.1016/j.bios.2013.11.059
PubMed: 24333932
Affiliations:
- États-Unis
- Californie, Pennsylvanie
- Los Angeles, Pittsburgh
- Université de Californie du Sud, Université de Pittsburgh
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Le document en format XML
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Division of Cardiology, Department of Medicine, VA Greater Los Angeles Healthcare System, School of Medicine, University of California, United States.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Biomedical Engineering, University of Southern California, Los Angeles, CA, United States; Division of Cardiology, Department of Medicine, VA Greater Los Angeles Healthcare System, School of Medicine, University of California</wicri:regionArea><orgName type="university">Université de Californie du Sud</orgName><placeName><settlement type="city">Los Angeles</settlement><region type="state">Californie</region></placeName></affiliation></author><author><name sortKey="Beebe, Tyler" sort="Beebe, Tyler" uniqKey="Beebe T" first="Tyler" last="Beebe">Tyler Beebe</name><affiliation wicri:level="4"><nlm:affiliation>Department of Biomedical Engineering, University of Southern California, Los Angeles, CA, United States; Division of Cardiology, Department of Medicine, VA Greater Los Angeles Healthcare System, School of Medicine, University of California, United States.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Biomedical Engineering, University of Southern California, Los Angeles, CA, United States; 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Electronic address: THsiai@mednet.ucla.edu.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Biomedical Engineering, University of Southern California, Los Angeles, CA, United States; Division of Cardiology, Department of Medicine, VA Greater Los Angeles Healthcare System, School of Medicine, University of California</wicri:regionArea><orgName type="university">Université de Californie du Sud</orgName><placeName><settlement type="city">Los Angeles</settlement><region type="state">Californie</region></placeName></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2014">2014</date><idno type="RBID">pubmed:24333932</idno><idno type="pmid">24333932</idno><idno type="doi">10.1016/j.bios.2013.11.059</idno><idno type="wicri:Area/PubMed/Corpus">003280</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">003280</idno><idno type="wicri:Area/PubMed/Curation">003258</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">003258</idno><idno type="wicri:Area/PubMed/Checkpoint">003258</idno><idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">003258</idno><idno type="wicri:Area/Ncbi/Merge">000844</idno><idno type="wicri:Area/Ncbi/Curation">000844</idno><idno type="wicri:Area/Ncbi/Checkpoint">000844</idno><idno type="wicri:Area/Main/Merge">001189</idno><idno type="wicri:Area/Main/Curation">001166</idno><idno type="wicri:Area/Main/Exploration">001166</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Stretchable electrochemical impedance sensors for intravascular detection of lipid-rich lesions in New Zealand White rabbits.</title><author><name sortKey="Cao, Hung" sort="Cao, Hung" uniqKey="Cao H" first="Hung" last="Cao">Hung Cao</name><affiliation wicri:level="4"><nlm:affiliation>Department of Biomedical Engineering, University of Southern California, Los Angeles, CA, United States; Division of Cardiology, Department of Medicine, VA Greater Los Angeles Healthcare System, School of Medicine, University of California, United States.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Biomedical Engineering, University of Southern California, Los Angeles, CA, United States; Division of Cardiology, Department of Medicine, VA Greater Los Angeles Healthcare System, School of Medicine, University of California</wicri:regionArea><orgName type="university">Université de Californie du Sud</orgName><placeName><settlement type="city">Los Angeles</settlement><region type="state">Californie</region></placeName></affiliation></author><author><name sortKey="Yu, Fei" sort="Yu, Fei" uniqKey="Yu F" first="Fei" last="Yu">Fei Yu</name><affiliation wicri:level="4"><nlm:affiliation>Department of Biomedical Engineering, University of Southern California, Los Angeles, CA, United States.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Biomedical Engineering, University of Southern California, Los Angeles, CA</wicri:regionArea><placeName><region type="state">Californie</region><settlement type="city">Los Angeles</settlement></placeName><orgName type="university">Université de Californie du Sud</orgName></affiliation></author><author><name sortKey="Zhao, Yu" sort="Zhao, Yu" uniqKey="Zhao Y" first="Yu" last="Zhao">Yu Zhao</name><affiliation wicri:level="2"><nlm:affiliation>Department of Electrical Engineering, California Institute of Technology, Pasadena, CA, United States.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Electrical Engineering, California Institute of Technology, Pasadena, CA</wicri:regionArea><placeName><region type="state">Californie</region></placeName></affiliation></author><author><name sortKey="Scianmarello, Nick" sort="Scianmarello, Nick" uniqKey="Scianmarello N" first="Nick" last="Scianmarello">Nick Scianmarello</name><affiliation wicri:level="2"><nlm:affiliation>Department of Electrical Engineering, California Institute of Technology, Pasadena, CA, United States.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Electrical Engineering, California Institute of Technology, Pasadena, CA</wicri:regionArea><placeName><region type="state">Californie</region></placeName></affiliation></author><author><name sortKey="Lee, Juhyun" sort="Lee, Juhyun" uniqKey="Lee J" first="Juhyun" last="Lee">Juhyun Lee</name><affiliation wicri:level="4"><nlm:affiliation>Department of Biomedical Engineering, University of Southern California, Los Angeles, CA, United States; Division of Cardiology, Department of Medicine, VA Greater Los Angeles Healthcare System, School of Medicine, University of California, United States.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Biomedical Engineering, University of Southern California, Los Angeles, CA, United States; Division of Cardiology, Department of Medicine, VA Greater Los Angeles Healthcare System, School of Medicine, University of California</wicri:regionArea><orgName type="university">Université de Californie du Sud</orgName><placeName><settlement type="city">Los Angeles</settlement><region type="state">Californie</region></placeName></affiliation></author><author><name sortKey="Dai, Wangde" sort="Dai, Wangde" uniqKey="Dai W" first="Wangde" last="Dai">Wangde Dai</name><affiliation wicri:level="2"><nlm:affiliation>The Heart Institute of Good Samaritan Hospital, Los Angeles, CA, United States.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>The Heart Institute of Good Samaritan Hospital, Los Angeles, CA</wicri:regionArea><placeName><region type="state">Californie</region></placeName></affiliation></author><author><name sortKey="Jen, Nelson" sort="Jen, Nelson" uniqKey="Jen N" first="Nelson" last="Jen">Nelson Jen</name><affiliation wicri:level="4"><nlm:affiliation>Department of Biomedical Engineering, University of Southern California, Los Angeles, CA, United States; Division of Cardiology, Department of Medicine, VA Greater Los Angeles Healthcare System, School of Medicine, University of California, United States.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Biomedical Engineering, University of Southern California, Los Angeles, CA, United States; Division of Cardiology, Department of Medicine, VA Greater Los Angeles Healthcare System, School of Medicine, University of California</wicri:regionArea><orgName type="university">Université de Californie du Sud</orgName><placeName><settlement type="city">Los Angeles</settlement><region type="state">Californie</region></placeName></affiliation></author><author><name sortKey="Beebe, Tyler" sort="Beebe, Tyler" uniqKey="Beebe T" first="Tyler" last="Beebe">Tyler Beebe</name><affiliation wicri:level="4"><nlm:affiliation>Department of Biomedical Engineering, University of Southern California, Los Angeles, CA, United States; Division of Cardiology, Department of Medicine, VA Greater Los Angeles Healthcare System, School of Medicine, University of California, United States.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Biomedical Engineering, University of Southern California, Los Angeles, CA, United States; Division of Cardiology, Department of Medicine, VA Greater Los Angeles Healthcare System, School of Medicine, University of California</wicri:regionArea><orgName type="university">Université de Californie du Sud</orgName><placeName><settlement type="city">Los Angeles</settlement><region type="state">Californie</region></placeName></affiliation></author><author><name sortKey="Li, Rongsong" sort="Li, Rongsong" uniqKey="Li R" first="Rongsong" last="Li">Rongsong Li</name><affiliation wicri:level="4"><nlm:affiliation>Department of Biomedical Engineering, University of Southern California, Los Angeles, CA, United States; Division of Cardiology, Department of Medicine, VA Greater Los Angeles Healthcare System, School of Medicine, University of California, United States.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Biomedical Engineering, University of Southern California, Los Angeles, CA, United States; Division of Cardiology, Department of Medicine, VA Greater Los Angeles Healthcare System, School of Medicine, University of California</wicri:regionArea><orgName type="university">Université de Californie du Sud</orgName><placeName><settlement type="city">Los Angeles</settlement><region type="state">Californie</region></placeName></affiliation></author><author><name sortKey="Ebrahimi, Ramin" sort="Ebrahimi, Ramin" uniqKey="Ebrahimi R" first="Ramin" last="Ebrahimi">Ramin Ebrahimi</name><affiliation wicri:level="1"><nlm:affiliation>Division of Cardiology, Department of Medicine, VA Greater Los Angeles Healthcare System, School of Medicine, University of California, United States.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Division of Cardiology, Department of Medicine, VA Greater Los Angeles Healthcare System, School of Medicine, University of California</wicri:regionArea><wicri:noRegion>University of California</wicri:noRegion></affiliation></author><author><name sortKey="Chang, Donald S" sort="Chang, Donald S" uniqKey="Chang D" first="Donald S" last="Chang">Donald S. Chang</name><affiliation wicri:level="1"><nlm:affiliation>Division of Cardiology, Department of Medicine, VA Greater Los Angeles Healthcare System, School of Medicine, University of California, United States.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Division of Cardiology, Department of Medicine, VA Greater Los Angeles Healthcare System, School of Medicine, University of California</wicri:regionArea><wicri:noRegion>University of California</wicri:noRegion></affiliation></author><author><name sortKey="Mody, Freny V" sort="Mody, Freny V" uniqKey="Mody F" first="Freny V" last="Mody">Freny V. Mody</name><affiliation wicri:level="1"><nlm:affiliation>Division of Cardiology, Department of Medicine, VA Greater Los Angeles Healthcare System, School of Medicine, University of California, United States.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Division of Cardiology, Department of Medicine, VA Greater Los Angeles Healthcare System, School of Medicine, University of California</wicri:regionArea><wicri:noRegion>University of California</wicri:noRegion></affiliation></author><author><name sortKey="Pacella, John" sort="Pacella, John" uniqKey="Pacella J" first="John" last="Pacella">John Pacella</name><affiliation wicri:level="4"><nlm:affiliation>Division of Cardiology, School of Medicine, University of Pittsburgh, Pittsburgh, PA, United States.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Division of Cardiology, School of Medicine, University of Pittsburgh, Pittsburgh, PA</wicri:regionArea><placeName><region type="state">Pennsylvanie</region><settlement type="city">Pittsburgh</settlement></placeName><orgName type="university">Université de Pittsburgh</orgName></affiliation></author><author><name sortKey="Tai, Yu Chong" sort="Tai, Yu Chong" uniqKey="Tai Y" first="Yu-Chong" last="Tai">Yu-Chong Tai</name><affiliation wicri:level="2"><nlm:affiliation>Department of Electrical Engineering, California Institute of Technology, Pasadena, CA, United States.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Electrical Engineering, California Institute of Technology, Pasadena, CA</wicri:regionArea><placeName><region type="state">Californie</region></placeName></affiliation></author><author><name sortKey="Hsiai, Tzung" sort="Hsiai, Tzung" uniqKey="Hsiai T" first="Tzung" last="Hsiai">Tzung Hsiai</name><affiliation wicri:level="4"><nlm:affiliation>Department of Biomedical Engineering, University of Southern California, Los Angeles, CA, United States; Division of Cardiology, Department of Medicine, VA Greater Los Angeles Healthcare System, School of Medicine, University of California, United States. Electronic address: THsiai@mednet.ucla.edu.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Biomedical Engineering, University of Southern California, Los Angeles, CA, United States; Division of Cardiology, Department of Medicine, VA Greater Los Angeles Healthcare System, School of Medicine, University of California</wicri:regionArea><orgName type="university">Université de Californie du Sud</orgName><placeName><settlement type="city">Los Angeles</settlement><region type="state">Californie</region></placeName></affiliation></author></analytic><series><title level="j">Biosensors & bioelectronics</title><idno type="eISSN">1873-4235</idno><imprint><date when="2014" type="published">2014</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animals</term><term>Aorta (pathology)</term><term>Atherosclerosis (diagnosis)</term><term>Atherosclerosis (pathology)</term><term>Biosensing Techniques (instrumentation)</term><term>Dielectric Spectroscopy (instrumentation)</term><term>Electric Impedance</term><term>Equipment Design</term><term>Lipids (analysis)</term><term>Lipoproteins, LDL (analysis)</term><term>Male</term><term>Plaque, Atherosclerotic (diagnosis)</term><term>Rabbits</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Animaux</term><term>Aorte (anatomopathologie)</term><term>Athérosclérose (anatomopathologie)</term><term>Athérosclérose (diagnostic)</term><term>Conception d'appareillage</term><term>Impédance électrique</term><term>Lapins</term><term>Lipides (analyse)</term><term>Lipoprotéines LDL (analyse)</term><term>Mâle</term><term>Plaque d'athérosclérose (diagnostic)</term><term>Spectroscopie diélectrique (instrumentation)</term><term>Techniques de biocapteur (instrumentation)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="analysis" xml:lang="en"><term>Lipids</term><term>Lipoproteins, LDL</term></keywords><keywords scheme="MESH" qualifier="analyse" xml:lang="fr"><term>Lipides</term><term>Lipoprotéines LDL</term></keywords><keywords scheme="MESH" qualifier="anatomopathologie" xml:lang="fr"><term>Aorte</term><term>Athérosclérose</term></keywords><keywords scheme="MESH" qualifier="diagnosis" xml:lang="en"><term>Atherosclerosis</term><term>Plaque, Atherosclerotic</term></keywords><keywords scheme="MESH" qualifier="diagnostic" xml:lang="fr"><term>Athérosclérose</term><term>Plaque d'athérosclérose</term></keywords><keywords scheme="MESH" qualifier="instrumentation" xml:lang="en"><term>Biosensing Techniques</term><term>Dielectric Spectroscopy</term></keywords><keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Aorta</term><term>Atherosclerosis</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Animals</term><term>Electric Impedance</term><term>Equipment Design</term><term>Male</term><term>Rabbits</term></keywords><keywords scheme="MESH" qualifier="instrumentation" xml:lang="fr"><term>Animaux</term><term>Conception d'appareillage</term><term>Impédance électrique</term><term>Lapins</term><term>Mâle</term><term>Spectroscopie diélectrique</term><term>Techniques de biocapteur</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Flexible electronics have enabled catheter-based intravascular sensing. However, real-time interrogation of unstable plaque remains an unmet clinical challenge. Here, we demonstrate the feasibility of stretchable electrochemical impedance spectroscopy (EIS) sensors for endoluminal investigations in New Zealand White (NZW) rabbits on diet-induced hyperlipidemia. A parylene C (PAC)-based EIS sensor mounted on the surface of an inflatable silicone balloon affixed to the tip of an interrogating catheter was deployed (1) on the explants of NZW rabbit aorta for detection of lipid-rich atherosclerotic lesions, and (2) on live animals for demonstration of balloon inflation and EIS measurements. An input peak-to-peak AC voltage of 10 mV and sweeping-frequency from 300 kHz to 100 Hz were delivered to the endoluminal sites. Balloon inflation allowed EIS sensors to be in contact with endoluminal surface. In the oxidized low-density-lipoprotein (oxLDL)-rich lesions from explants of fat-fed rabbits, impedance magnitude increased significantly by 1.5-fold across the entire frequency band, and phase shifted ~5° at frequencies below 10 kHz. In the lesion-free sites of the normal diet-fed rabbits, impedance magnitude increased by 1.2-fold and phase shifted ~5° at frequencies above 30 kHz. Thus, we demonstrate the feasibility of stretchable intravascular EIS sensors for identification of lipid rich lesions, with a translational implication for detecting unstable lesions.</div></front></TEI><affiliations><list><country><li>États-Unis</li></country><region><li>Californie</li><li>Pennsylvanie</li></region><settlement><li>Los Angeles</li><li>Pittsburgh</li></settlement><orgName><li>Université de Californie du Sud</li><li>Université de Pittsburgh</li></orgName></list><tree><country name="États-Unis"><region name="Californie"><name sortKey="Cao, Hung" sort="Cao, Hung" uniqKey="Cao H" first="Hung" last="Cao">Hung Cao</name></region><name sortKey="Beebe, Tyler" sort="Beebe, Tyler" uniqKey="Beebe T" first="Tyler" last="Beebe">Tyler Beebe</name><name sortKey="Chang, Donald S" sort="Chang, Donald S" uniqKey="Chang D" first="Donald S" last="Chang">Donald S. Chang</name><name sortKey="Dai, Wangde" sort="Dai, Wangde" uniqKey="Dai W" first="Wangde" last="Dai">Wangde Dai</name><name sortKey="Ebrahimi, Ramin" sort="Ebrahimi, Ramin" uniqKey="Ebrahimi R" first="Ramin" last="Ebrahimi">Ramin Ebrahimi</name><name sortKey="Hsiai, Tzung" sort="Hsiai, Tzung" uniqKey="Hsiai T" first="Tzung" last="Hsiai">Tzung Hsiai</name><name sortKey="Jen, Nelson" sort="Jen, Nelson" uniqKey="Jen N" first="Nelson" last="Jen">Nelson Jen</name><name sortKey="Lee, Juhyun" sort="Lee, Juhyun" uniqKey="Lee J" first="Juhyun" last="Lee">Juhyun Lee</name><name sortKey="Li, Rongsong" sort="Li, Rongsong" uniqKey="Li R" first="Rongsong" last="Li">Rongsong Li</name><name sortKey="Mody, Freny V" sort="Mody, Freny V" uniqKey="Mody F" first="Freny V" last="Mody">Freny V. Mody</name><name sortKey="Pacella, John" sort="Pacella, John" uniqKey="Pacella J" first="John" last="Pacella">John Pacella</name><name sortKey="Scianmarello, Nick" sort="Scianmarello, Nick" uniqKey="Scianmarello N" first="Nick" last="Scianmarello">Nick Scianmarello</name><name sortKey="Tai, Yu Chong" sort="Tai, Yu Chong" uniqKey="Tai Y" first="Yu-Chong" last="Tai">Yu-Chong Tai</name><name sortKey="Yu, Fei" sort="Yu, Fei" uniqKey="Yu F" first="Fei" last="Yu">Fei Yu</name><name sortKey="Zhao, Yu" sort="Zhao, Yu" uniqKey="Zhao Y" first="Yu" last="Zhao">Yu Zhao</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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